Career Opportunities


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Post Doc Fellow, Biochemistry Division, Chemistry, Grillo Lab 

Application: https://jobs.uc.edu/job/Cincinnati-Post-Doc-Fellow%2C-Biochemistry-Division%2C-Chemistry%2C-Grillo-Lab-OH-45201/932055400/

Job Overview

The Grillo Lab (www.grillolabuc.com) is seeking candidates to join our vibrant team in a full-time position as a Postdoctoral Fellow. Research in the Grillo Lab focuses on the molecular understanding of how age-related or environmental-induced mitochondrial dysfunction alters metabolism in neurologic disease. Our research at the interface of biochemistry, metabolism, and physiology employs multiple in vitro and in vivo models to investigate the basic biochemistry and molecular mechanisms of inborn errors of metabolism (e.g. branched chain amino acid deficiencies) and age-progressive neurodegenerative diseases (e.g. tauopathies).

Candidates with a strong background in mitochondrial metabolism, biochemistry, cell biology, aging, hypoxia, mTOR, or metal biology in neurodegenerative diseases are especially encouraged to apply. The postdoctoral scientist will perform laboratory experiments on an independent project under the supervision of Dr. Grillo while assisting other laboratory personnel. The target start date is October 1st, although timing can be flexible.

Essential Functions

  • Independently perform research experiments on an independent project and properly record data according to research protocols under the mentorship of Dr. Grillo.
  • Troubleshoot experimental protocols, organize complex data, and analyze/interpret results within the context of the overarching research project.
  • Read, analyze, evaluate, and critique primary research to enhance expertise.
  • Actively help and/or train other laboratory personnel including postdoctoral scientists, graduate students, and undergraduate students based on professional training or functional experience.
  • Establish and manage collaborations between diverse research laboratories.
  • Effectively communicate experimental hypotheses, protocols, analyses, results, and project details in one-on-one or group meetings, journal clubs, conferences, etc.
  • Actively participate in the writing of research papers, grants, and other documents.
  • Attend scientific conferences, meetings, and workshops to enhance the career development of the candidate.
  • Apply for extramural funding and training opportunities.
  • Mentor junior trainees to enhance their career development.
  • Demonstrate continual success in performing increasingly complex experiments or projects that require improved technical skills.
  • Perform related duties based on laboratory needs. This job description may change as the research project progresses.

Required Education

Ph.D. in biochemistry, cell biology, physiology, chemical biology, neuroscience, or other health-related discipline at the time of appointment.

Additional Qualifications Considered

  • Strong record of research accomplishments and peer-reviewed publications.
  • Demonstrated oral and written communication skills through previous publications and conference presentations.
  • Presentations of scientific results at national meetings.
  • Expertise in mitochondrial metabolism, hypoxia, mTOR, and/or metals in age-related neurodegenerative diseases.
  • Experience working with mouse models of human disease.
  • Experience in isolating primary neurons, cell culture, and aseptic technique.
  • Previous work with iPSC-derived neurons.

Application Process

Applicants must upload the following materials as a single document:

  • Cover Letter accepted
  • CV
  • A research statement highlighting previous research and impact (1-2 pages)
  • A short statement of long-term research interests and goals (<1 page)
  • May add up to three relevant publications
  • Confidential letter(s) of recommendation sent to Dr. Grillo ([email protected]) from recommender(s). A maximum of three will be accepted.

The University of Cincinnati, as a multi-national and culturally diverse university, is committed to providing an inclusive, equitable and diverse place of learning and employment. As part of a complete job application, you will be asked to include a Contribution to Diversity and Inclusion statement. The University of Cincinnati is an Affirmative Action / Equal Opportunity Employer / Minority / Female / Disability / Veteran.

 


Post-doctoral Fellow position

A full-time Post-doctoral Fellow position is available in the Ahn laboratory. The fellow will have opportunities to investigate the role of ghrelin and mitochondria on muscle weakness in cancer cachexia and sarcopenia. The lab is currently funded to perform skeletal muscle research, while aiming to add cardiac research in these pathological conditions. Ahn lab belongs to the Section of Gerontology and Geriatric Medicine, Department of Internal Medicine at Wake Forest University Baptist School of Medicine.

We are a basic science laboratory testing an intervention using ghrelin on sarcopenia and cancer cachexia, while elucidating mechanisms of muscle wasting and weakness using transgenic mouse models. The lab is currently funded to test the role of unacylated ghrelin in sarcopenia and cancer cachexia. We will use various experimental techniques ranging from cell cultures, state-of-the-art mitochondrial functional assays (high resolution respirometry and fluorometry), muscle contractile function assays, and a wide variety of molecular biology assays, and unbiased omics approaches (RNAseq, proteomics, and metabolomics). The lab is involved in clinical research with the faculty in the Claude Pepper Older Americans Independence Center and will have access to human muscle biopsies from large clinical trials in the elderly. In parallel, we also investigate the effect of redox imbalance in the pathogenesis of cancer cachexia. Several unique gain-of-function and loss-of-function models are used to test the causal effects of oxidative stress and free radicals in muscle wasting and weakness. With the lab’s expertise in mitochondrial bioenergetics, there will be collaborative opportunities with multiple research groups at the Wake Forest Medical Center.

Atrium Health Wake Forest Baptist is a preeminent academic health system based in Winston-Salem, North Carolina and part of Atrium Health Enterprise. Atrium Health Wake Forest Baptist’s two main components are an integrated clinical system – anchored by Atrium Health Wake Forest Baptist Medical Center, an 885-bed tertiary-care hospital in Winston-Salem, that includes Brenner Children’s Hospital, five community hospitals, more than 300 primary and specialty care locations and more than 2,700 physicians; and Wake Forest University School of Medicine, the academic core of Atrium Health Enterprise and a recognized leader in experiential medical education and groundbreaking research that includes Wake Forest Innovations, a commercialization enterprise focused on advancing health care through new medical technologies and biomedical discovery.

Postdoctoral fellow will receive structured and extensive training by the PI and collaborating investigators in the department of Internal Medicine. The fellow is expected to design and conduct research experiments; manage research projects; prepare reports and papers for publication, presentation, and future research; contribute to grant writing and are encouraged to write applications for fellowships. Candidates with US citizenship or residency may be able to apply for a T32 postdoctoral fellowship.

Qualifications:

  • PhD, MD, or equivalent degree in biomedical sciences
  • Fluent writing and verbal communication skills in English
  • Preferred) a track record of productivity
  • Preferred) experience in mitochondrial bioenergetics, redox biology, or muscle research

Application Instructions:

Interested candidates should submit the following documents via email to: [email protected] 1) a cover letter outlining your research interests and goals, and 2) a curriculum vitae (CV) that includes lists of publications and contact information for three professional references. Reference letters are not required at this stage but will be considered during the final selection process.